Publications | Yves De Koninck laboratory

2020

Ferrini F, Perez-Sanchez J, Ferland S, Lorenzo L-E, Godin AG, Plasencia-Fernández I, Cottet M, Castonguay A, Wang F, Salio C et al.. 2020. Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization.. Nat Commun. 11(1):3935.

Lorenzo L-E, Godin AG, Ferrini F, Bachand K, Plasencia-Fernández I, Labrecque S, Girard AA, Boudreau D, Kianicka I, Gagnon M et al.. 2020. Enhancing neuronal chloride extrusion rescues α2/α3 GABA-mediated analgesia in neuropathic pain.. Nat Commun. 11(1):869.

Dong W, Jin SChih, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo L-E, Islam B, Brindle G et al.. 2020. Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.. iScience. 23(10):101552.

2019

Mapplebeck JCS, Lorenzo L-E, Lee KYeop, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. 2019. Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.. Cell Rep. 28(3):590-596.e4.

Dedek A, Xu J, Kandegedara CM, Lorenzo L-E, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME. 2019. Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.. Brain. 142(6):1535-1546.

Castonguay A, Lorenzo L-E, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y, Godin AG. 2019. Revealing Abnormal Oligomerization of Proteins in Single Cells. 116(3, Supplement 1):426a.

Richner M, Pallesen LT, Ulrichsen M, Poulsen ET, Holm TH, Login H, Castonguay A, Lorenzo L-E, Gonçalves NP, Andersen OM et al.. 2019. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain.. Sci Adv. 5(6):eaav9946.

2017

Ferrini F, Lorenzo L-E, Godin AG, Le Quang M, De Koninck Y. 2017. Enhancing KCC2 function counteracts morphine-induced hyperalgesia.. Sci Rep. 7(1):3870.

Gagnon M, Bergeron MJ, Perez-Sanchez J, Plasencia-Fernández I, Lorenzo L-E, Godin AG, Castonguay A, Bonin RP, De Koninck Y. 2017. Reply to The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.. Nat Med. 23(12):1396-1398.

Echeverry S, Shi XQun, Yang M, Huang H, Wu YC, Lorenzo L-E, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J. 2017. Spinal microglia are required for long-term maintenance of neuropathic pain.. Pain. 158(9):1792-1801.

Perez-Sanchez J, Lorenzo L-E, Lecker I, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y, Bonin RP. 2017. α5GABA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia.. J Neurosci Res. 95(6):1307-1318.

2016

Binan L, Mazzaferri J, Choquet K, Lorenzo L-E, Wang YChang, Affar EBachir, De Koninck Y, Ragoussis J, Kleinman CL, Costantino S. 2016. Live single-cell laser tag.. Nat Commun. 7:11636.

2014

Lorenzo L-E, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y. 2014. Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors.. J Neurosci. 34(24):8300-17.

Lorenzo L-E, Magnussen C, Bailey AL, St Louis M, De Koninck Y, Ribeiro-da-Silva A. 2014. Spatial and temporal pattern of changes in the number of GAD65-immunoreactive inhibitory terminals in the rat superficial dorsal horn following peripheral nerve injury.. Mol Pain. 10:57.

2013

Ferrini F, Trang T, Mattioli T-AM, Laffray S, Del'Guidice T, Lorenzo L-E, Castonguay A, Doyon N, Zhang W, Godin AG et al.. 2013. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.. Nat Neurosci. 16(2):183-92.

2011

Godin AG, Costantino S, Lorenzo L-E, Swift JL, Sergeev M, Ribeiro-da-Silva A, De Koninck Y, Wiseman PW. 2011. Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis.. Proc Natl Acad Sci U S A. 108(17):7010-5.

2009

Labrakakis C, Lorenzo L-E, Bories C, Ribeiro-da-Silva A, De Koninck Y. 2009. Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn.. Mol Pain. 5:24.

2008

Lorenzo L-E, Ramien M, St Louis M, De Koninck Y, Ribeiro-da-Silva A. 2008. Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat.. J Comp Neurol. 508(4):592-604.