Page last updated - 2022-11-11
Also view our most recent publications in our online profiles
Khademullah CS, De Koninck Y. A novel assessment of fine-motor function reveals early hindlimb and detectable forelimb deficits in an experimental model of ALS. Sci Rep. 2022 Oct 11;12(1):17010. doi: 10.1038/s41598-022-20333-1. PubMed PMID: 36220871; PubMed Central PMCID: PMC9553953.
Wong C, Barkai O, Wang F, Perez CT, Lev S, Cai W, Tansley S, Yousefpour N, Hooshmandi M, Lister KC, Latif M, Cuello AC, Prager-Khoutorsky M, Mogil JS, Séguéla P, De Koninck Y, Ribeiro-da-Silva A, Binshtok AM, Khoutorsky A. mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. J Clin Invest. 2022 Aug 1;132(15). doi: 10.1172/JCI152635. PubMed PMID: 35579957; PubMed Central PMCID: PMC9337825.
Aby F, Lorenzo LE, Grivet Z, Bouali-Benazzouz R, Martin H, Valerio S, Whitestone S, Isabel D, Idi W, Bouchatta O, De Deurwaerdere P, Godin AG, Herry C, Fioramonti X, Landry M, De Koninck Y, Fossat P. Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Sci Adv. 2022 Jul 29;8(30):eabo0689. doi: 10.1126/sciadv.abo0689. Epub 2022 Jul 27. PubMed PMID: 35895817; PubMed Central PMCID: PMC9328683.
Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister KC, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A. Microglia-mediated degradation of perineuronal nets promotes pain. Science. 2022 Jul;377(6601):80-86. doi: 10.1126/science.abl6773. Epub 2022 May 26. PubMed PMID: 35617374.
Ruthazer ES, Béïque JC, De Koninck Y. Editorial: Shedding Light on the Nervous System: Progress in Neurophotonics Research. Front Neural Circuits. 2022;16:901376. doi: 10.3389/fncir.2022.901376. eCollection 2022. PubMed PMID: 35664457; PubMed Central PMCID: PMC9156792.
Dedek A, Xu J, Lorenzo LÉ, Godin AG, Kandegedara CM, Glavina G, Landrigan JA, Lombroso PJ, De Koninck Y, Tsai EC, Hildebrand ME. Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain. Brain. 2022 Apr 29;145(3):1124-1138. doi: 10.1093/brain/awab408. PubMed PMID: 35323848; PubMed Central PMCID: PMC9050559.
LeBlanc A, Baron M, Blouin P, Tarabulsy G, Routhier F, Mercier C, Despres JP, Hébert M, De Koninck Y, Cellard C, Collin-Vézina D, Côté N, Dionne É, Fleet R, Gagné MH, Isabelle M, Lessard L, Menear M, Merette C, Ouellet MC, Roy MA, Saint-Jacques MC, Savard C. For a structured response to the psychosocial consequences of the restrictive measures imposed by the global COVID-19 health pandemic: the MAVIPAN longitudinal prospective cohort study protocol. BMJ Open. 2022 Apr 4;12(4):e048749. doi: 10.1136/bmjopen-2021-048749. PubMed PMID: 35379610; PubMed Central PMCID: PMC8980732.
Paige C, Plasencia-Fernandez I, Kume M, Papalampropoulou-Tsiridou M, Lorenzo LE, David ET, He L, Mejia GL, Driskill C, Ferrini F, Feldhaus AL, Garcia-Martinez LF, Akopian AN, De Koninck Y, Dussor G, Price TJ. A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models. J Neurosci. 2022 Mar 9;42(10):1930-1944. doi: 10.1523/JNEUROSCI.1137-21.2022. Epub 2022 Jan 20. PubMed PMID: 35058371; PubMed Central PMCID: PMC8916765.
Menard C, Siddiqui TJ, Sargin D, Lawson A, De Koninck Y, Illes J. The Canadian Brain Research Strategy: A Focus on Early Career Researchers. Can J Neurol Sci. 2022 Mar;49(2):168-170. doi: 10.1017/cjn.2021.81. Epub 2021 Apr 27. PubMed PMID: 33902769.
Quaglio G, Toia P, Moser EI, Karapiperis T, Amunts K, Okabe S, Poo MM, Rah JC, Koninck Y, Ngai J, Richards L, Bjaalie JG. The International Brain Initiative: enabling collaborative science. Lancet Neurol. 2021 Dec;20(12):985-986. doi: 10.1016/S1474-4422(21)00389-6. PubMed PMID: 34800415.
Perreault ML, King M, Gabel C, Mushquash CJ, De Koninck Y, Lawson A, Marra C, Ménard C, Young JZ, Illes J. An Indigenous Lens on Priorities for the Canadian Brain Research Strategy. Can J Neurol Sci. 2021 Dec 1;:1-3. doi: 10.1017/cjn.2021.501. [Epub ahead of print] PubMed PMID: 34847973.
Bilodeau G, Gagnon-Turcotte G, Gagnon LL, Keramidis I, Timofeev I, De Koninck Y, Ethier C, Gosselin B. A Wireless Electro-Optic Platform for Multimodal Electrophysiology and Optogenetics in Freely Moving Rodents. Front Neurosci. 2021;15:718478. doi: 10.3389/fnins.2021.718478. eCollection 2021. PubMed PMID: 34504415; PubMed Central PMCID: PMC8422428.
López-Cano M, Font J, Aso E, Sahlholm K, Cabré G, Giraldo J, De Koninck Y, Hernando J, Llebaria A, Fernández-Dueñas V, Ciruela F. Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects. Br J Pharmacol. 2021 Aug 6;. doi: 10.1111/bph.15645. [Epub ahead of print] PubMed PMID: 34363210.
Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LÉ, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, Dunbar A, Nelson-Williams C, Kiziltug E, Furey CG, Conine S, Duy PQ, Kundishora AJ, Loring E, Li B, Lu Q, Zhou G, Liu W, Li X, Sierant MC, Mane S, Castaldi C, López-Giráldez F, Knight JR, Sekula RF Jr, Simard JM, Eskandar EN, Gottschalk C, Moliterno J, Günel M, Gerrard JL, Dib-Hajj S, Waxman SG, Barker FG 2nd, Alper SL, Chahine M, Haider S, De Koninck Y, Lifton RP, Kahle KT. Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia. iScience. 2020 Oct 23;23(10):101552. doi: 10.1016/j.isci.2020.101552. eCollection 2020 Oct 23. PubMed PMID: 33083721; PubMed Central PMCID: PMC7554653.
Mailhot B, Christin M, Tessandier N, Sotoudeh C, Bretheau F, Turmel R, Pellerin È, Wang F, Bories C, Joly-Beauparlant C, De Koninck Y, Droit A, Cicchetti F, Scherrer G, Boilard E, Sharif-Naeini R, Lacroix S. Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases. J Exp Med. 2020 Sep 7;217(9). doi: 10.1084/jem.20191430. PubMed PMID: 32573694; PubMed Central PMCID: PMC7478735.
Ferrini F, Perez-Sanchez J, Ferland S, Lorenzo LE, Godin AG, Plasencia-Fernandez I, Cottet M, Castonguay A, Wang F, Salio C, Doyon N, Merighi A, De Koninck Y. Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization. Nat Commun. 2020 Aug 7;11(1):3935. doi: 10.1038/s41467-020-17824-y. PubMed PMID: 32769979; PubMed Central PMCID: PMC7414850.
Papalampropoulou-Tsiridou M, Labrecque S, Godin AG, De Koninck Y, Wang F. Differential Expression of Acid - Sensing Ion Channels in Mouse Primary Afferents in Naïve and Injured Conditions. Front Cell Neurosci. 2020;14:103. doi: 10.3389/fncel.2020.00103. eCollection 2020. PubMed PMID: 32508593; PubMed Central PMCID: PMC7248332.
Li Q, Siri T, Bressan C, de Koninck Y, Saghatelyan A. Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain. Stem Cell Reports. 2020 Apr 14;14(4):692-702. doi: 10.1016/j.stemcr.2020.03.008. Epub 2020 Apr 2. PubMed PMID: 32243847; PubMed Central PMCID: PMC7160358.
DePaoli D, Gasecka A, Bahdine M, Deschenes JM, Goetz L, Perez-Sanchez J, Bonin RP, De Koninck Y, Parent M, Côté DC. Anisotropic light scattering from myelinated axons in the spinal cord. Neurophotonics. 2020 Jan;7(1):015011. doi: 10.1117/1.NPh.7.1.015011. Epub 2020 Mar 10. PubMed PMID: 32206678; PubMed Central PMCID: PMC7063473.
International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts. Neuron. 2020 Mar 4;105(5):947. doi: 10.1016/j.neuron.2020.02.022. PubMed PMID: 32135092.
Khademullah CS, Aqrabawi AJ, Place KM, Dargaei Z, Liang X, Pressey JC, Bedard S, Yang JW, Garand D, Keramidis I, Gasecka A, Côté D, De Koninck Y, Keith J, Zinman L, Robertson J, Kim JC, Woodin MA. Cortical interneuron-mediated inhibition delays the onset of amyotrophic lateral sclerosis. Brain. 2020 Mar 1;143(3):800-810. doi: 10.1093/brain/awaa034. PubMed PMID: 32203578.
Lorenzo LE, Godin AG, Ferrini F, Bachand K, Plasencia-Fernandez I, Labrecque S, Girard AA, Boudreau D, Kianicka I, Gagnon M, Doyon N, Ribeiro-da-Silva A, De Koninck Y. Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain. Nat Commun. 2020 Feb 13;11(1):869. doi: 10.1038/s41467-019-14154-6. PubMed PMID: 32054836; PubMed Central PMCID: PMC7018745.
International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts. Neuron. 2020 Jan 22;105(2):212-216. doi: 10.1016/j.neuron.2020.01.002. PubMed PMID: 31972144.
Gagnon-Turcotte G, Keramidis I, Ethier C, De Koninck Y, Gosselin B. A Wireless Electro-Optic Headstage With a 0.13- μm CMOS Custom Integrated DWT Neural Signal Decoder for Closed-Loop Optogenetics. IEEE Trans Biomed Circuits Syst. 2019 Oct;13(5):1036-1051. doi: 10.1109/TBCAS.2019.2930498. Epub 2019 Jul 23. PubMed PMID: 31352352.
Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. Cell Rep. 2019 Jul 16;28(3):590-596.e4. doi: 10.1016/j.celrep.2019.06.059. PubMed PMID: 31315039.
Richner M, Pallesen LT, Ulrichsen M, Poulsen ET, Holm TH, Login H, Castonguay A, Lorenzo LE, Gonçalves NP, Andersen OM, Lykke-Hartmann K, Enghild JJ, Rønn LCB, Malik IJ, De Koninck Y, Bjerrum OJ, Vægter CB, Nykjær A. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Sci Adv. 2019 Jun;5(6):eaav9946. doi: 10.1126/sciadv.aav9946. eCollection 2019 Jun. PubMed PMID: 31223654; PubMed Central PMCID: PMC6584543.
Dedek A, Xu J, Kandegedara CM, Lorenzo LÉ, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME. Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing. Brain. 2019 Jun 1;142(6):1535-1546. doi: 10.1093/brain/awz105. PubMed PMID: 31135041; PubMed Central PMCID: PMC6536915.
Illes J, Weiss S, Bains J, Chandler JA, Conrod P, De Koninck Y, Fellows LK, Groetzinger D, Racine E, Robillard JM, Sokolowski MB. A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy. Neuron. 2019 Feb 6;101(3):370-374. doi: 10.1016/j.neuron.2018.12.021. PubMed PMID: 30731060.
Battaglia M, Rossignol O, Bachand K, D'Amato FR, De Koninck Y. Amiloride modulation of carbon dioxide hypersensitivity and thermal nociceptive hypersensitivity induced by interference with early maternal environment. J Psychopharmacol. 2019 Jan;33(1):101-108. doi: 10.1177/0269881118784872. Epub 2018 Jul 3. PubMed PMID: 29968500.
Thibon L, Piché M, De Koninck Y. Resolution enhancement in laser scanning microscopy with deconvolution switching laser modes (D-SLAM). Opt Express. 2018 Sep 17;26(19):24881-24903. doi: 10.1364/OE.26.024881. PubMed PMID: 30469598.
Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 Jul;19(7):383-384. doi: 10.1038/s41583-018-0012-5. PubMed PMID: 29765159; PubMed Central PMCID: PMC6237656.
Khiarak MN, Martianova E, Bories C, Martel S, Proulx CD, De Koninck Y, Gosselin B. A Wireless Fiber Photometry System Based on a High-Precision CMOS Biosensor With Embedded Continuous-Time Modulation. IEEE Trans Biomed Circuits Syst. 2018 Jun;12(3):495-509. doi: 10.1109/TBCAS.2018.2817200. PubMed PMID: 29877814.
Wang F, Bélanger E, Côté SL, Desrosiers P, Prescott SA, Côté DC, De Koninck Y. Sensory Afferents Use Different Coding Strategies for Heat and Cold. Cell Rep. 2018 May 15;23(7):2001-2013. doi: 10.1016/j.celrep.2018.04.065. PubMed PMID: 29768200.
Rezaei M, Maghsoudloo E, Bories C, De Koninck Y, Gosselin B. A Low-Power Current-Reuse Analog Front-End for High-Density Neural Recording Implants. IEEE Trans Biomed Circuits Syst. 2018 Apr;12(2):271-280. doi: 10.1109/TBCAS.2018.2805278. PubMed PMID: 29570055.
Gagnon M, Bergeron MJ, Perez-Sanchez J, Plasencia-Fernández I, Lorenzo LE, Godin AG, Castonguay A, Bonin RP, De Koninck Y. Reply to The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity. Nat Med. 2017 Dec 7;23(12):1396-1398. doi: 10.1038/nm.4449. PubMed PMID: 29216044.
Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Uvarov P, Kwan J, Bagshaw RD, Pawson T, Emili A, De Koninck Y, Anggono V, Airaksinen M, Woodin MA. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife. 2017 Oct 13;6. doi: 10.7554/eLife.28270. PubMed PMID: 29028184; PubMed Central PMCID: PMC5640428.
Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J. Spinal microglia are required for long-term maintenance of neuropathic pain. Pain. 2017 Sep;158(9):1792-1801. doi: 10.1097/j.pain.0000000000000982. PubMed PMID: 28746078.
Ferrini F, Lorenzo LE, Godin AG, Quang ML, De Koninck Y. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870. doi: 10.1038/s41598-017-04209-3. PubMed PMID: 28634406; PubMed Central PMCID: PMC5478677.
Perez-Sanchez J, Lorenzo LE, Lecker I, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y, Bonin RP. α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia. J Neurosci Res. 2017 Jun;95(6):1307-1318. doi: 10.1002/jnr.23981. Epub 2016 Oct 28. PubMed PMID: 27792253.
Bories C, Arsenault D, Lemire M, Tremblay C, De Koninck Y, Calon F. Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease. Aging (Albany NY). 2017 May 16;9(5):1386-1403. doi: 10.18632/aging.101239. PubMed PMID: 28522792; PubMed Central PMCID: PMC5472739.
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankara JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents. Nat Med. 2017 Mar;23(3):355-360. doi: 10.1038/nm.4281. Epub 2017 Jan 30. PubMed PMID: 28134928.
Choinière M, Ware MA, Pagé MG, Lacasse A, Lanctôt H, Beaudet N, Boulanger A, Bourgault P, Cloutier C, Coupal L, De Koninck Y, Dion D, Dolbec P, Germain L, Martin V, Sarret P, Shir Y, Taillefer MC, Tousignant B, Trépanier A, Truchon R. Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry. Pain Res Manag. 2017;2017:8123812. doi: 10.1155/2017/8123812. Epub 2017 Feb 9. PubMed PMID: 28280406; PubMed Central PMCID: PMC5322414.
Thibon L, Lorenzo LE, Piché M, De Koninck Y. Resolution enhancement in confocal microscopy using Bessel-Gauss beams. Opt Express. 2017 Feb 6;25(3):2162-2177. doi: 10.1364/OE.25.002162. PubMed PMID: 29519064.
Gagnon-Turcotte G, LeChasseur Y, Bories C, Messaddeq Y, De Koninck Y, Gosselin B. A Wireless Headstage for Combined Optogenetics and Multichannel Electrophysiological Recording. IEEE Trans Biomed Circuits Syst. 2017 Feb;11(1):1-14. doi: 10.1109/TBCAS.2016.2547864. Epub 2016 Jun 20. PubMed PMID: 27337721.
Gagnon D, Petryszyn S, Sanchez MG, Bories C, Beaulieu JM, De Koninck Y, Parent A, Parent M. Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice. Sci Rep. 2017 Jan 27;7:41432. doi: 10.1038/srep41432. PubMed PMID: 28128287; PubMed Central PMCID: PMC5269744.
Wang F, Bélanger E, Paquet ME, Côté DC, De Koninck Y. Probing pain pathways with light. Neuroscience. 2016 Dec 3;338:248-271. doi: 10.1016/j.neuroscience.2016.09.035. Epub 2016 Oct 1. Review. PubMed PMID: 27702648.
Zussy C, Loustalot F, Junyent F, Gardoni F, Bories C, Valero J, Desarménien MG, Bernex F, Henaff D, Bayo-Puxan N, Chen JW, Lonjon N, de Koninck Y, Malva JO, Bergelson JM, di Luca M, Schiavo G, Salinas S, Kremer EJ. Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity. J Neurosci. 2016 Sep 14;36(37):9558-71. doi: 10.1523/JNEUROSCI.0132-16.2016. PubMed PMID: 27629708; PubMed Central PMCID: PMC6601941.
Miraucourt LS, Tsui J, Gobert D, Desjardins JF, Schohl A, Sild M, Spratt P, Castonguay A, De Koninck Y, Marsh-Armstrong N, Wiseman PW, Ruthazer ES. Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells. Elife. 2016 Aug 8;5. doi: 10.7554/eLife.15932. PubMed PMID: 27501334; PubMed Central PMCID: PMC4987138.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016 Aug;13(8):673-8. doi: 10.1038/nmeth.3894. Epub 2016 Jun 6. PubMed PMID: 27271196; PubMed Central PMCID: PMC5312699.
Binan L, Mazzaferri J, Choquet K, Lorenzo LE, Wang YC, Affar EB, De Koninck Y, Ragoussis J, Kleinman CL, Costantino S. Live single-cell laser tag. Nat Commun. 2016 May 20;7:11636. doi: 10.1038/ncomms11636. PubMed PMID: 27198043; PubMed Central PMCID: PMC4876456.
View more on Yves De Koninck's online profiles