Affiliated with Université Laval & CERVO Research Centre


Yves De Koninck featured in Nature's neuropod podcast


Listen to Yves De Koninck in conversation with Kerri Smith explain the recent publication by Bonin and De Koninck in Nature Neuroscience.
Go to the Nature website and select the third segment.

Discovery of a new means to erase pain


A study published in the scientific journal Nature Neuroscience by Yves De Koninck and Robert Bonin reveals that it is possible to relieve pain hypersensitivity using a new method that involves rekindling pain so that it can subsequently be erased. This discovery could lead to novel means to alleviate chronic pain.

Université Laval published a press release about this important discovery

Read the original research article in Nature...


Chronic Pain comes out of its silence - Interview with Yves De Koninck


Découvrir, the magazine of the Association Francophone pour le Savoir (ACFAS), published an interview about chronic pain with Quebec Pain Research Network founder Yves De Koninck. Read the interview on the ACFAS website:

Images by Louis-Etienne Lorenzo, Feng Wang and Erik Bélanger finalists for the ACFAS 2014 image contest


Two images from the YDK lab are finalists for the ACFAS 2014 image contest:  "Un portrait de la douleur", by Louis-Étienne Lorenzo, and "Dans le vif du sujet" by Feng Wang and Erik Bélanger.

View all the images in the contest here:

Université Laval and Roche team up to test promising new drugs


Université Laval and Roche recently signed a collaborative research agreement to test promising compounds for several disorders of the brain, including autism spectrum disorders (ASD).

Thanks to this joint initiative, Yves De Koninck and his team will be able to pursue the development of the many scientific discoveries and advances they have made in the last 10 years. The joint research program will focus on evaluating the potential of various molecules affecting the activity of a protein called KCC2 normally present in neurons of the brain and spinal cord. Dr. De Koninck’s recent...


Québec Science Top 10 discoveries of 2013 for discovery of mechanism explaining morphine induced hyperalgesia


Recent discoveries  explaining the mechanism of morphine induced hyperalgesia have been named one of the top 10 discoveries of 2013 by Québec Science.

Congratulations to co-first authors Francesco Ferrini & Tuan Trang and the rest of the team! 


Top 10 scientific breakthroughs of 2013 - Le Soleil: Chronic Pain under siege


Research done in the YDK lab are recognized as one of the top ten scientific breakthroughs of 2013, according to Le Soleil newspaper: 

Identifying the part of the cell that causes a disease. Understanding where, exactly, the mechanism breaks.  Finding a drug to repair it.  In biomedical research, this is probably what approaches the definition of a »hat trick» And it is what the team of Yves De Koninck, neuroscientist at Université Laval, have just done in the fight against chronic pain.

Read the complete article in ...


Yves De Koninck named Scientific Director of the Institut universitaire en santé mentale de Québec


Congratulations to Yves De Koninck, who was named the new Scientific Director of the Institut universitaire en santé mentale de Québec.  Learn more about this nomination here:

Personality of the week La Presse Radio Canada: Yves De Koninck


Yves De Koninck personality of the week La Presse Radio-Canada for the week of October 21 2013, in recognition of his recent discoveries that could lead to the development of new pain relief drugs, and for receiving the Jacques Rousseau prize for multidisciplinarity.

Read this story in La Presse.

Discovery of a new drug target for chronic pain and other neurological disorders


The identification of compounds that can restore normal chloride levels in cells shows promise to treat several neurological and psychiatric disorders, including epilepsy, motor spasticity, stress, anxiety, schizophrenia, morphine-induced hyperalgesia and chronic pain.  New results published by the De Koninck laboratory in Nature Medicine shows one such compounds was able to alleviate hypersensitivity in a rat chronic pain model.  These results suggest drugs targeting chloride extrusion could lead to the development of novel treatments for chronic pain and many more neurological disorders...



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