Affiliated with Université Laval & CERVO Research Centre


Uncovering how morphine increases pain in some people


Recent discoveries published in Nature Neuroscience "identifies a molecular pathway by which morphine can increase pain, and suggests potential new ways to make morphine effective for more patients" says Yves De Koninck, senior author of the paper. 

The research not only identifies a target pathway to suppress morphine-induced pain but teases apart the pain hypersensitivity caused by morphine from tolerance to morphine, two phenomena previously considered to be caused by the same mechanisms.

"When morphine doesn't reduce pain adequately the tendency is to increase the dosage...


Top 10 discoveries of the year 2011 Québec Science


Research leading to the development of a micro-optrode allowing optical and electrical recording from a single neuron in vivo was recognized as one of the top 10 discoveries of the year by Québec Science. Congratulations to Yoann Lechasseur and the whole team!

Original research article: LeChasseur Y, Dufour S, Lavertu G, Bories C, Deschênes M, Vallée R, De Koninck Y....


New method to measure protein interactions in vivo


In two articles published in the Proceedings of the National Academies of Science (PNAS), Yves De Koninck, Jean-Martin Beaulieu, Paul Wiseman and their teams describe a new technique, spatial intensity distribution analysis, to study protein-protein interactions in intact tissue by optical microscopy.  

Read an article about this discovery in Le Fil - Université Laval - La valse des protéines en direct
Des chercheurs mettent au point une méthode pour mesurer in vivo les...



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