Affiliated with Université Laval and the CERVO Research Centre

Discoveries

New publication in Nature Medicine shows existing drugs can alleviate morphine withdrawal

2017-03-08

A recent publication in Nature Medicine co-authored by Robert Bonin and Yves De Koninck offers new hope for people addicted to morphine and fentanyl.  By  investigating the underlying causes of withdrawal symptoms, the researchers identified a protein located in immune cells of the spinal cord called pannexin-1 as a major player, which lead them to look for drugs that block pannexin-1 as a way to alleviate symptoms.  The team found a drug previously approved to treat gout, called probenecid, that worked in this way.  Importantly, the drug does not affect the ability of opioids to relieve...

read more...

Cover of Journal of Neuroscience

2016-09-16

The Journal of Neuroscience has recently featured on its front page a figure from an article De Koninck laboratory members contributed to. The article studies the localisation of a specific receptor on neurons, the Coxsackievirus Adenovirus Receptor (CAR), in healthy brains, but also during development and in neurodegenerative disease conditions. The study suggests CAR has a role in adult neurogenesis, synapses, and plasticity in the hippocampus.
View the about the cover section: http://www.jneurosci.org/content/36/...

read more...

Teaching the Nervous System to Forget Chronic Pain

2014-08-18

Research recently published by the De Koninck lab showed that hyperalgesia could be reversed when reactivated, in a manner similar to memory reconsolidation.  This important discovery was recently featured on PBS's NovaNext website 

The original research was published in Nature Neuroscience

Discovery of a new means to erase pain

2014-07-10

A study published in the scientific journal Nature Neuroscience by Yves De Koninck and Robert Bonin reveals that it is possible to relieve pain hypersensitivity using a new method that involves rekindling pain so that it can subsequently be erased. This discovery could lead to novel means to alleviate chronic pain.

Université Laval published a press release about this important discovery

Read the original research article in Nature...

read more...

Université Laval and Roche team up to test promising new drugs

2014-01-13

Université Laval and Roche recently signed a collaborative research agreement to test promising compounds for several disorders of the brain, including autism spectrum disorders (ASD).

Thanks to this joint initiative, Yves De Koninck and his team will be able to pursue the development of the many scientific discoveries and advances they have made in the last 10 years. The joint research program will focus on evaluating the potential of various molecules affecting the activity of a protein called KCC2 normally present in neurons of the brain and spinal cord. Dr. De Koninck’s recent...

read more...

Discovery of a new drug target for chronic pain and other neurological disorders

2013-10-10

The identification of compounds that can restore normal chloride levels in cells shows promise to treat several neurological and psychiatric disorders, including epilepsy, motor spasticity, stress, anxiety, schizophrenia, morphine-induced hyperalgesia and chronic pain.  New results published by the De Koninck laboratory in Nature Medicine shows one such compounds was able to alleviate hypersensitivity in a rat chronic pain model.  These results suggest drugs targeting chloride extrusion could lead to the development of novel treatments for chronic pain and many more neurological disorders...

read more...

A multimodal micro-optrode - blog post on openoptogeneticsblog.org

2013-04-15

Read A multimodal micro-optrode - a blog post in openoptogenetics about the multimodal micro-optrodes developed by Yoann Lechasseur, Suzie Dufour and the rest of the YDK lab team and collaborators:

http://openoptogeneticsblog.org/?p=550

The post discusses two papers

  • A microprobe for parallel optical and electrical recordings from single neurons in vivo Nature Methods 8, 319–325 (2011) doi:10.1038/nmeth.1572
    by Yoan LeChasseur, Suzie Dufour, Guillaume Lavertu, Cyril Bories, Martin Deschênes, Réal Vallée...
read more...

Uncovering how morphine increases pain in some people

2013-01-12

Recent discoveries published in Nature Neuroscience "identifies a molecular pathway by which morphine can increase pain, and suggests potential new ways to make morphine effective for more patients" says Yves De Koninck, senior author of the paper. 

The research not only identifies a target pathway to suppress morphine-induced pain but teases apart the pain hypersensitivity caused by morphine from tolerance to morphine, two phenomena previously considered to be caused by the same mechanisms.

"When morphine doesn't reduce pain adequately the tendency is to increase the dosage...

read more...

Top 10 discoveries of the year 2011 Québec Science

2011-12-15

Research leading to the development of a micro-optrode allowing optical and electrical recording from a single neuron in vivo was recognized as one of the top 10 discoveries of the year by Québec Science. Congratulations to Yoann Lechasseur and the whole team!

http://www.quebecscience.qc.ca/les-10-decouvertes-2011/1-Lumiere-sur-les...

Original research article: LeChasseur Y, Dufour S, Lavertu G, Bories C, Deschênes M, Vallée R, De Koninck Y....

read more...

New method to measure protein interactions in vivo

2011-04-20

In two articles published in the Proceedings of the National Academies of Science (PNAS), Yves De Koninck, Jean-Martin Beaulieu, Paul Wiseman and their teams describe a new technique, spatial intensity distribution analysis, to study protein-protein interactions in intact tissue by optical microscopy.  

Read an article about this discovery in Le Fil - Université Laval - La valse des protéines en direct
Des chercheurs mettent au point une méthode pour mesurer in vivo les...

read more...
Subscribe to Discoveries