Apr
20
2011
By Julie
In two articles published in the Proceedings of the National Academies of Science (PNAS), Yves De Koninck, Jean-Martin Beaulieu, Paul Wiseman and their teams describe a new technique, spatial intensity distribution analysis, to study protein-protein interactions in intact tissue by optical microscopy.
Read an article about this discovery in Le Fil - Université Laval - La valse des protéines en direct
Des chercheurs mettent au point une méthode pour mesurer in vivo les interactions entre protéines
Read the abstracts of the two articles in PNAS
- Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7010-5. doi: 10.1073/pnas.1018658108. Epub 2011 Apr 11. - Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells.
Swift JL, Godin AG, Doré K, Freland L, Bouchard N, Nimmo C, Sergeev M, De Koninck Y, Wiseman PW, Beaulieu JM.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7016-21. doi: 10.1073/pnas.1018280108. Epub 2011 Apr 11.
Go to our tools section to download SPIDA - Spatial Intensity Distribution Analysis Software
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