Affiliated with Université Laval & CERVO Research Centre

Louis-Etienne Lorenzo

Louis-Etienne Lorenzo

 


Mailing Address: 

CERVO Brain Research Centre - 2601 Chemin de la Canardière F-5573 Québec QUEBEC G1J 2G3 Canada






Current position: 
Research Associate

Research interests

Our research focuses on the synaptic plasticity in the Central Nervous System (CNS) with a particular emphasis on cellular substrates in pathological conditions. This research area includes the study of the synaptic plasticity of neurons in their connections and receptors as well their interaction with glial cells in various physiological and pathological conditions. My most recent work focuses on four main themes: [1] the synaptic mechanisms in the sensory spinal cord and their plasticity in pathological conditions in experimental models of chronic pain and autism. This includes the study of the inhibitory synaptic plasticity (GABAergic/glycinergic) and of the chloride homeostasis (neuronal ionic transporters like KCC2 and NKCC1). [2] The involvement of multiple immune inflammatory mediators  in the CNS or at the periphery, in various diseases. The consequences at the spinal cord and brain levels. [3] The role of GPCRs (G-Protein Coupled Receptors) like the Neurokinin-1 receptor in nociception and pain transmission. [4] Differences in neurobiological mechanisms between male and female animals.

In addition to the classical collaborative work between biologists and geneticists, our current projects require close interactions with biophysicists and mathematicians. We are trying to develop new mathematical and analytical tools which could be broadly applied to biology and neuroscience in the future.

Research areas

Cellular neurobiology, spinal cord, sensory and motor physiology, neuronal excitability, synaptic transmission and plasticity, GABAA and GABAB receptors, glycine receptors, membrane biophysics, chloride homeostasis, K+/Cl- Cotransporters (NKCC1/KCC2), KCC2 enhancers, GPCR, Neurokinin-1 receptor, drug development.

Illnesses under study

Chronic pain, Austism, Neurodegenration, Amyotrophic Lateral Sclerosis

Technologies

Immunohisto- and cytochemistry, cellular imaging, confocal and electron microscopy, fluorescence spectroscopy, non-linear microscopy, signal analysis and new image analytic tools, super-resolution microscopy, in vivo and in vitro optogenetics, nanotechnologies, pharmacology, behavioral measurements, preclinical studies, RT-qPCR (Real Time quantitative Polymerase Chain Reaction), computer simulations, RNAscope.