Affiliated with Université Laval & CERVO Research Centre

Découverte de l'année Québec Science 2013: Le double jeu de la morphine

2013: Le double jeu de la morphine

For explaining why morphine can paradoxically cause pain, and showing that the mechanisms underlying pain hypersensitivity are distinct from those causing morphine tolerance. 

Original research article: Ferrini F, Trang T, Mattioli TA, Laffray S, Del'Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. Nat Neurosci. 2013 Feb;16(2):183-92. doi: 10.1038/nn.3295. Epub 2013 Jan 6.