Affiliated with Université Laval & CERVO Research Centre

A spinal analog of memory reconsolidation enables reversal of hyperalgesia.

TitleA spinal analog of memory reconsolidation enables reversal of hyperalgesia.
Publication TypeJournal Article
Year of Publication2014
AuthorsBonin RP, De Koninck Y
JournalNat Neurosci
Volume17
Issue8
Pagination1043-5
Date Published2014 Aug
ISSN1546-1726
KeywordsAnimals, Anisomycin, Capsaicin, Central Nervous System Sensitization, Disease Models, Animal, Hyperalgesia, Male, Memory, Mice, Mice, Inbred C57BL, Pain, Posterior Horn Cells, Protein Synthesis Inhibitors, Sensory System Agents, Spinal Cord
Abstract

<p>Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.</p>

DOI10.1038/nn.3758
Alternate JournalNat. Neurosci.
PubMed ID24997764
PubMed Central IDPMC4978538
Grant List124953-1 / / Canadian Institutes of Health Research / Canada
MOP 12942 / / Canadian Institutes of Health Research / Canada