Affiliated with Université Laval & CERVO Research Centre

Optrodes for combined optogenetics and electrophysiology in live animals.

TitleOptrodes for combined optogenetics and electrophysiology in live animals.
Publication TypeJournal Article
Year of Publication2015
AuthorsDufour S, De Koninck Y
Date Published2015 Jul

<p>Optical tissue properties limit visible light depth penetration in tissue. Because of this, the recent development of optogenetic tools was quickly followed by the development of light delivery devices for in vivo optogenetics applications. We summarize the efforts made in the last decade to design neural probes that combine conventional electrophysiological recordings and optical channel(s) for optogenetic activation, often referred to as optodes or optrodes. Several aspects including challenges for light delivery in living brain tissue, the combination of light delivery with electrophysiological recordings, probe designs, multimodality, wireless implantable system, and practical considerations guiding the choice of configuration depending on the questions one seeks to address are presented.</p>

Alternate JournalNeurophotonics
PubMed ID26158014
PubMed Central IDPMC4489589