|Title||Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Doyon N, Vinay L, Prescott SA, De Koninck Y|
|Date Published||2016 Mar 16|
|Keywords||Animals, Chlorides, Homeostasis, Humans, Models, Biological, Neural Inhibition, Nonlinear Dynamics, Synapses|
Fast synaptic inhibition relies on tight regulation of intracellular Cl(-). Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl(-) dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl(-) dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl(-) is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl(-) regulation is energetically so expensive, and the overall consequences for therapeutics.
|Grant List||/ / Canadian Institutes of Health Research / Canada|