Affiliated with Université Laval & CERVO Research Centre

Louis-Etienne Lorenzo

Louis-Etienne Lorenzo

 


Mailing Address: 

CRIUSMQ 2601 Chemin de la Canardière F-5573 Québec QUEBEC G1J 2G3 Canada






Current position: 
Research Associate

Research interests

Our research focuses on the synaptic plasticity in the Central Nervous System (CNS) with a particular emphasis on cellular substrates in pathological conditions. This research area includes the study of the synaptic plasticity of neurons in their connections and receptors as well their interaction with glial cells in various physiological and pathological conditions. My most recent work focuses on three main themes: [1] the synaptic mechanisms in the sensory spinal cord and their plasticity in pathological conditions in experimental models of chronic pain and autism. This includes the study of the inhibitory synaptic transmission plasticity (GABAergic/glycinergic) and of the chloride homeostasis with the study of neuronal ionic transporters like KCC2 and NKCC1. [2] The involvement of multiple inflammatory mediators of immune cells in the CNS and at the periphery in different diseases. The consequences on the spinal cord and brain. [3] The role of GPCRs (G-Protein Coupled Receptors) like the Neurokinin-1 receptor in nociception and pain transmission.

In addition to the classical collaborative work between biologists and geneticists, all this work requires closed collaboration with biophysicists and mathematicians. We are trying to develop new mathematical and analytical tools that could be broadly applied to neuroscience and biology in the future.

Research areas

Cellular neurobiology, spinal cord, sensory and motor physiology, neuronal excitability, synaptic transmission and plasticity, GABAA and GABAB receptors, glycine receptors,  membrane biophysics, chloride homeostasis, K+/Cl- Cotransporters (NKCC1/KCC2), KCC2 enhancers,  GPCR, Neurokinin-1 receptor, drug development.

Illnesses under study

Chronic pain, Autism, Neurodegeneration, Amyotrophic Lateral Sclerosis

Technology

Immunohisto- and cytochemistry, cellular imaging, confocal and electron microscopy,    fluorescence spectroscopy, non-linear microscopy, signal analysis and new analytic tools, super-resolution microscopy, in vivo and in vitro optogenetics, nanotechnologies, pharmacology, behavioral measurements, preclinical studies, RT-qPCR (Real Time quantitative Polymerase Chain Reaction), computer simulations, electrophysiology.