Affiliated with Université Laval & CERVO Research Centre

Normal and abnormal coding of somatosensory stimuli causing pain.

TitleNormal and abnormal coding of somatosensory stimuli causing pain.
Publication TypeJournal Article
Year of Publication2014
AuthorsPrescott SA, Ma Q, De Koninck Y
JournalNat Neurosci
Volume17
Issue2
Pagination183-91
Date Published2014 Feb
ISSN1546-1726
KeywordsAfferent Pathways, Animals, Humans, Models, Biological, Nociceptors, Pain, Perception, Physical Stimulation
Abstract

Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.

DOI10.1038/nn.3629
Alternate JournalNat. Neurosci.
PubMed ID24473266
PubMed Central IDPMC4079041
Grant ListR01 NS076706 / NS / NINDS NIH HHS / United States
MOP 12942 / / Canadian Institutes of Health Research / Canada
R01 NS086372 / NS / NINDS NIH HHS / United States
P01 NS072040 / NS / NINDS NIH HHS / United States
P01 NS0272040 / NS / NINDS NIH HHS / United States
R21 NS074146 / NS / NINDS NIH HHS / United States
R01 DE018025 / DE / NIDCR NIH HHS / United States
R01 NS047710 / NS / NINDS NIH HHS / United States