Affiliated with Université Laval & CERVO Research Centre

Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.

TitleChloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.
Publication TypeJournal Article
Year of Publication2016
AuthorsDoyon N, Vinay L, Prescott SA, De Koninck Y
JournalNeuron
Volume89
Issue6
Pagination1157-1172
Date Published2016 Mar 16
ISSN1097-4199
KeywordsAnimals, Chlorides, Homeostasis, Humans, Models, Biological, Neural Inhibition, Nonlinear Dynamics, Synapses
Abstract

Fast synaptic inhibition relies on tight regulation of intracellular Cl(-). Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl(-) dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl(-) dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl(-) is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl(-) regulation is energetically so expensive, and the overall consequences for therapeutics.

DOI10.1016/j.neuron.2016.02.030
Alternate JournalNeuron
PubMed ID26985723
Grant List / / Canadian Institutes of Health Research / Canada